A Metabolic Switch for Th17 Pathogenicity
نویسندگان
چکیده
T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis.
منابع مشابه
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
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عنوان ژورنال:
- Cell
دوره 163 شماره
صفحات -
تاریخ انتشار 2015